The film received positive feedback from critics. Review aggregator Rotten Tomatoes reports that 93% of 170 film critics have given the film a positive review, with a rating average of 7.7 out of 10.[10] Metacritic, which assigns a weighted average score out of 100 to reviews from mainstream critics, gives the film a score of 72 based on 40 reviews.[11]
Sean Burns wrote in the
Philadelphia Weekly that Levine "knows how to stay out of the way long enough to let a very talented cast shine, and Rogen's fundamental, unexpected decency, which can often only be expressed through shoulder-punching obscenities, grows more quietly moving as the picture wears on."[12]
David Schmader, writing in the Stranger, praises "50/50's stellar cast, from the omnipresent lead Joseph Gordon-Levitt (whose Rankin/Bass puppet face is put to beautifully nuanced use) to the all-star supporting cast: Anjelica Huston roars back to prominence with a twisty performance as Adam's barely contained mess of a mom, and Anna Kendrick's young doctoral student makes the film's rom-com aspirations not-ridiculous with her intelligent spontaneity and huge cute teeth. But the comedy star is Seth Rogen, cast in the same role he played in screenwriter Reiser's life.
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